Dr. David M. Cole

Post-doctoral Researcher

Bio.

I completed a PhD at Imperial College London’s Computational, Cognitive and Clinical Neuroimaging Lab. (C³NL), under the supervision of Prof. Christian Beckmann and Prof. Tom Nichols. In this work I used resting-state fMRI to examine the effects of neurochemical (in particular dopaminergic) modulations on large-scale network functional connectivity in the human brain. I also investigated the interactions between variability in such systems-level phenomena and individual differences in cognitive factors. Much of this research stemmed from valuable collaborations with, among other colleagues, Prof. Serge Rombouts (Leiden Institute for Brain and Cognition), Prof. Paul Matthews (Imperial College London and GlaxoSmithKline) and the Imanova Centre for Imaging Sciences (formerly the GSK Clinical Imaging Centre). More recently I undertook a short post-doctoral position at the University of Oxford Centre for Functional MRI of the Brain (FMRIB, with Dr. Sonia Bishop).

Having trained originally as an experimental psychologist and cognitive neuroscientist (BSc, MSc, University of York), with a range of academic and industry experiences in EEG, MEG, MRI and PET recording and analysis techniques, I am now based (since May 2013) at the TNU in Zurich working with Prof. Klaas Enno Stephan. My post-doctoral research bridges the divide between neuropsychiatry and computational neuroscience by way of (i) behavioural probes of impulsivity in decision-making, (ii) biophysical/computational modelling of behaviour, brain activity and connectivity, (iii) functional neuroimaging and (iv) psychopharmacology of neuromodulatory monoaminergic (dopamine, noradrenaline and serotonin) systems.

 

Research funding:

KFSP Molecular Imaging Network Zurich (MINZ): 2013 – 2016

 

Teaching:

Joint Analysis of EEG & fMRI – Computational Psychiatry: EEG signal processing, Spring Semester 2015

Resting-state fMRI – Zurich SPM Course, 3-6 February 2015

Computational Psychiatry: Neuropharmacology, Spring Semester 2014 (course co-organiser)

— Methods & Models for fMRI Data Analysis – Spatial Preprocessing of fMRI Data

 

Selected publications:

  • Cole DM, Beckmann CF, Oei NYL, Both S, van Gerven JMA, Rombouts SARB (2013). Differential and distributed effects of dopamine neuromodulations on resting-state network connectivity. NeuroImage 78:59-67.
  • Cole DM, Oei NYL, Soeter RP, Both S, van Gerven JMA, Rombouts SARB, Beckmann CF (2013). Dopamine-dependent architecture of cortico-subcortical network connectivity. Cerebral Cortex 23:1509-1516.
  • Cole DM, Beckmann CF, Searle GE, Plisson C, Tziortzi AC, Nichols TE, Gunn RN, Matthews PM, Rabiner EA, Beaver JD (2012). Orbitofrontal connectivity with resting-state networks is associated with midbrain dopamine D3 receptor availability. Cerebral Cortex 22:2784-2793.
  • Klumpers LE, Cole DM, Khalili-Mahani N, Soeter RP, te Beek ET, Rombouts SARB, van Gerven JMA (2012). Manipulating brain connectivity with δ9-tetrahydrocannabinol: a pharmacological resting state FMRI study. NeuroImage 63:1701-1711.
  • Voets NL, Beckmann CF, Cole DM, Hong SJ, Bernasconi A, Bernasconi N (2012). Structural substrates for resting network disruption in temporal lobe epilepsy. Brain 135:2350-2357.
  • Beaver JD, Long CJ, Cole DM, Durcan MJ, Bannon LC, Mishra RG, Matthews PM (2011). The effects of nicotine replacement on cognitive brain activity during smoking withdrawal studied with simultaneous fMRI/EEG. Neuropsychopharmacology 36:1792-1800.
  • Cole DM, Beckmann CF, Long CJ, Matthews PM, Durcan MJ, Beaver JD (2010). Nicotine replacement in abstinent smokers improves cognitive withdrawal symptoms with modulation of resting brain network dynamics. NeuroImage 52:590-599.
  • Cole DM, Smith SM, Beckmann CF (2010). Advances and pitfalls in the analysis and interpretation of resting-state FMRI data. Frontiers in Systems Neuroscience 4:8.

 

More detailed publication information is available on my Google Scholar profile:

http://scholar.google.com/citations?user=ufueppkAAAAJ&hl=en

 

Frontiers: http://community.frontiersin.org/people/DavidCole/11512

 

ResearchGate: https://www.researchgate.net/profile/David_Cole5

 

Contact:

cole[at]biomed[dot]ee[dot]ethz[dot]ch